Proton pump inhibitors were introduced in 1980 for the treatment of heartburn, ulcers and Gastroesophageal reflux disease (GERD).
Omeprazole was the first drug in this class, introduced in 1989. Since then, four other PPIs viz lansoprazole, rabeprazole, pantoprazole and esomeprazole have been introduced in 1995, 1999, 2000 and 2001 respective
Proton Pump Inhibitors
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